The Atlanta-born talent was best known for Clueless (1995) and 8 Mile (2002) with Eminem, but she also costarred in Girl, Interrupted (1999) with Angelina Jolie and was cast as the lead in the rom-coms Little Black Book (2004) and Just Married (2003), in which she starred alongside her real-life boyfriend at the time, Ashton Kutcher.

Murphy also made a splash on the music scene with DJ Paul Oakenfold via their single "Faster Kill Pussycat," which became a club hit and reached No. 1 on Billboard's Hot Dance Club Play chart in 2006.